DOCK8 Rabbit Monoclonal Antibody-EnkiLife

DOCK8 Rabbit Monoclonal Antibody

Cat: AMRe01922

Size:50μL Price:$158
Size:100μL Price:$288
Size:200μL Price:$520
Application:WB,ICC/IF
Reactivity:Human
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:DOCK8 Category: 組換えモノクローナル抗体 Tags: Cardiovascular, Rabbit, Unconjugated, WB, IF, Human

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Summary

Production Name	DOCK8 Rabbit Monoclonal Antibody
Description	Recombinant rabbit monoclonal antibody
Host	Rabbit
Application	WB,ICC/IF
Reactivity	Human

Performance

Conjugation	Unconjugated
Modification	Unmodified
Isotype	IgG
Clonality	Monoclonal
Form	Liquid
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Buffer	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Purification	Affinity Purification

Immunogen

Gene Name	DOCK8
Alternative Names	MRD2; ZIR8; HEL-205
Gene ID	81704
SwissProt ID	Q8NF50

Application

Dilution Ratio	WB 1:500-1:1000,ICC/IF 1:50-1:200
Molecular Weight	Calculated MW: 239 kDa; Observed MW: 239 kDa

Background

Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC . Required for CD4+ T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780).

Research Area

Cardiovascular