PTTG1_HUMAN O95997
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UniProt:O95997
Recommended name：Securin
EC number：
Alternative names：(Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG)
Cleaved into：
GeneID：9232
Gene names (primary )：PTTG1
Gene names (synonym )：EAP1 PTTG TUTR1
Gene names (ORF )：
Length：202
Mass：22024
Sequence：MATLIYVDKENGEPGTRVVAKDGLKLGSGPSIKALDGRSQVSTPRFGKTFDAPPALPKATRKALGTVNRATEKSVKTKGPLKQKQPSFSAKKMTEKTVKAKSSVPASDDAYPEIEKFFPFNPLDFESFDLPEEHQIAHLPLSGVPLMILDEERELEKLFQLGPPSPVKMPSPPWESNLLQSPSSILSTLDVELPPVCCDIDI
Tissue specificity：Expressed at low level in most tissues, except in adult testis, where it is highly expressed. Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer. {ECO:0000269|PubMed:9811450}.
Induction：
Developmental stage：Low level during G1 and S phases. Peaks at M phase. During anaphase, it is degraded.
Protein families：Securin family