NOLC1 Rabbit Monoclonal antibody-EnkiLife

NOLC1 Rabbit Monoclonal antibody

Summary

Production Name	NOLC1 Rabbit Monoclonal antibody
Description	Recombinant rabbit monoclonal antibody
Host	Rabbit
Application	WB,IHC,ICC/IF
Reactivity	Human

Performance

Conjugation	Unconjugated
Modification	Unmodified
Isotype	IgG
Clonality	Monoclonal Antibody
Form	Liquid
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Buffer	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Purification	Affinity Purified

Immunogen

Gene Name	NOLC1
Alternative Names	P130; NOPP130; NOPP140; NS5ATP13
Gene ID	9221
SwissProt ID	Q14978

Application

Dilution Ratio	WB 1:500-1:1000,IHC 1:50-1:100,ICC/IF 1:50-1:200
Molecular Weight	Calculated MW: 74 kDa; Observed MW: 110 kDa

Background

Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786).

Research Area

Epigenetics and Nuclear Signaling