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CBX4 (10P4) Rabbit Monoclonal Antibody

CBX4 (10P4) Rabbit Monoclonal Antibody

Cat: AMRe08056
Size:50μL Price:$128
Size:100μL Price:$230
Size:200μL Price:$380
Application:WB,IHC,FC,IP,IF-P
Reactivity:Human,Mouse,Rat
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:CBX4 Category: 組換えモノクローナル抗体 Tags:

Summary

Production Name

CBX4 (10P4) Rabbit Monoclonal Antibody

Description

Recombinant rabbit monoclonal antibody

Host

Rabbit

Application

WB,IHC,FC,IP,IF-P

Reactivity

Human,Mouse,Rat

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG

Clonality

Monoclonal

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Purification

Affinity purification

 

Immunogen

Gene Name

CBX4

Alternative Names

CBX4; hPc2; NBP16; PC2;

Gene ID

8535

SwissProt ID

O00257

 

Application

Dilution Ratio

WB 1:500-1:2000,IHC 1:100-1:200,FC 1:200-1:500,IP 1:20-1:50,IF-P 1:100-1:200

Molecular Weight

61kDa

 

Background

E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I (PubMed:12679040). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850).

 

Research Area

Epigenetics and Nuclear Signaling

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